id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-319248-ynoxec7k	Matsuyama, Toshifumi	An aberrant STAT pathway is central to COVID-19	2020-10-09		.txt	text/plain	9962	619	45	In SARS-CoV-2-infected cells, a positive feedback loop established between STAT3 and plasminogen activator inhibitor-1 (PAI-1) may lead to an escalating cycle of activation in common with the interdependent signaling networks affected in COVID-19. After a careful review of the scientific literature, we realized that the SARS-CoV-2-mediated inhibition of IFN and STAT1, and the subsequent shift to a STAT3dominant signaling network (see below), could result in almost all of the clinical features of COVID-19. Molecular patterns derived from SARS-CoV-2-associated molecules, such as ssRNA, dsRNA, and viral proteins, bind to host PRRs and trigger the activation of signal transducers and transcription factors that drive the production of IFN-I and proinflammatory cytokines and chemokines. Therefore, in COVID-19, EGFR signaling may become an alternative pathway that activates STAT3 specifically when the lung is damaged while the production of IFN-I is severely impaired by SARS-CoV-2 infection [12] .	./cache/cord-319248-ynoxec7k.txt	./txt/cord-319248-ynoxec7k.txt