id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-320389-zgujsi9c	Kalfaoglu, Bahire	T-cell dysregulation in COVID-19	2020-11-07		.txt	text/plain	3855	205	45	Particularly, we highlight the impairment of FOXP3 induction in CD4(+) T-cells and how the impaired FOXP3 expression can lead to the differentiation of abnormally activated (hyperactivated) T-cells and the dysregulated T-cell responses in severe patients. SARS-CoV-2-infected epithelial cells can detect viral RNA by cytosolic sensors including RIG-1 and MDA5 and produce type-I IFNs, which induces IFN-mediated anti-viral responses [22] . These collectively suggest that the impairment of FOXP3 induction in severe COVID-19 induces autoimmune-like T-cell responses to self-antigens, which deplete immunological resources that could have been used by virus-specific T-cells. In addition, FURIN expression is induced in T-cells by TCR signalling in vivo and in vitro [33] , and therefore, FOXP3 + Treg and highly activated CD25 + CD4 + T-cells could potentially enhance the activation of S protein in inflammatory tissues. Collectively, FOXP3 -CD25 + CD4 + T-cells in severe COVID-19 patients are considered to be abnormally activated (hyperactivated), failing to differentiate into specific T-cell subsets.	./cache/cord-320389-zgujsi9c.txt	./txt/cord-320389-zgujsi9c.txt