id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-321960-p4twpm2z	Thibaudin, Marion	Immunological features of coronavirus disease 2019 in patients with cancer	2020-09-07		.txt	text/plain	3149	186	48	CONCLUSION: SARS-CoV-2 infection in cancer patients is associated with CD4 T cell lymphopenia with induction of an inflammatory T-cell response, accumulation of IFNγ(+) TNFα(+) CD8 T and Th17 cells, and a concomitant modification of monocyte activation status. Regarding maturation of monocytes, we observed that HLA-DR low monocytes, which harbor a monocytic MDSC phenotype, were increased in COVID-19-positive cancer patients, while HLA-DR high -activated monocytes were decreased ( Figure 3B ). Together these data underline the induction of CD3 lymphopenia, with an inversion of the CD4/CD8 ratio, a change in monocyte activation, accumulation of mMDSC-like cells and a decrease in activated monocytes in COVID-19 positive cancer patients. Interestingly, we observed in the basal peripheral blood a marked decrease in HLA-DR expression in CD8 T cells in COVID-19-positive patients ( Figure 4D) , which is marker of T cell activation [10, 11] .	./cache/cord-321960-p4twpm2z.txt	./txt/cord-321960-p4twpm2z.txt