id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-322596-vfmzk2el	Ming, Yi	Involvement of Spike Protein, Furin, and ACE2 in SARS-CoV-2-Related Cardiovascular Complications	2020-07-11		.txt	text/plain	3595	193	43	Current clinical reports indicate that SARS-CoV-2 is associated with significant morbidity of cardiovascular diseases and complications, such as hypertension (HTN), myocarditis, acute myocardial infarction, and increased heart failure [5, 6] . Based on these theoretical assumptions, it can be concluded that the S protein/host furin/ACE2 signal axis exists in the pathological process of SARS-Cov-S2 infection and mediates the occurrence of adverse cardiovascular prognosis events. Furthermore, a unique furin-like cleavage site exists in the S protein of SARS-Cov-S2 [16] ; thus, the theoretical advantage inferred from this cleavage site in disease infection models can be deduced to prevent and combat COVID-19 caused by SARS-CoV-2. However, in the process of infection, the S protein plays a direct damaging role by recognizing and binding to the ACE2 receptor and invading the host cell [10] . Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein	./cache/cord-322596-vfmzk2el.txt	./txt/cord-322596-vfmzk2el.txt