id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-322866-au76nnzg	Bleizgys, Andrius	Vitamin D and COVID‐19: It is time to act	2020-10-27		.txt	text/plain	6022	317	51	High‐dose VitD supplementation, particularly for risk groups, could be recommended to achieve and maintain optimal (range 40‐60 ng/mL) serum 25‐hydroxy vitamin D levels (marker of VitD status) both for COVID‐19 prevention and treatment. 17, 19, 26 Epidemiological studies of the past showed inverse relationships between VitD status and certain clinical events: lower 25OH-D levels are associated with higher risk of developing ARDS, heart failure and sepsis; the latter conditions are also known to increase risk for severe COVID-19 and death from COVID-19. Some authors even suggested that patients having VitD deficiency should be considered as high risk group for getting severe illness from COVID-19. 44, 45 VitD also increases the gene expression of antioxidative enzymes, eg glutathione reductase and glutamate-cysteine ligase modifier subunit, and this was shown to help maintain higher levels of vitamin C, which is an antioxidant and has antimicrobial activity as well, and is suggested as a potential agent for fighting COVID-19.	./cache/cord-322866-au76nnzg.txt	./txt/cord-322866-au76nnzg.txt