id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-323327-08p122lw	van de Veerdonk, Frank L.	Blocking IL-1 to prevent respiratory failure in COVID-19	2020-07-18		.txt	text/plain	3019	145	41	These findings open new avenues for host-directed therapies in patients with symptomatic SARS-CoV-2 infection and might in addition to antiviral treatment be enough to curb the currently unacceptably high morbidity and mortality associated with COVID-19. Although ICU patients have been treated with glucocorticoids, some experts have even argued, based on studies in Middle-Eastern respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome (SARS), influenza, and respiratory syncytial virus (RSV), that they are likely to do more harm than good [1, 2] . The autoinflammatory loop can exacerbate from increase innate immune response into uncontrolled MAS a spectrum that associates with increasing ferritin levels van de Veerdonk and Netea Critical Care (2020) 24:445 patients in the early phase and reports that high dose intravenous anakinra started in patients outside of the ICU was safe and resulted in clinical benefit in 72% of patients [56] .	./cache/cord-323327-08p122lw.txt	./txt/cord-323327-08p122lw.txt