id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-324041-lqokztor	Saussez, Sven	Anosmia: an evolution of our understanding of its importance in COVID-19 and what questions remain to be answered	2020-09-09		.txt	text/plain	3081	139	43	RESULTS: In terms of the etiology of olfactory dysfunction, several hypotheses were proposed at the outset of the pandemic; that olfactory cleft inflammation and obstruction caused a localized conductive loss, that there was injury to the sustentacular supporting cells in the olfactory epithelium or, given the known neurotropic potential of coronavirus, that the virus could invade and damage the olfactory bulb. While self-reported new onset loss of smell is important from an infection control perspective, as it allows patients to recognize COVID infection and self-isolate at an early stage; however, psychophysical testing has demonstrated that self-reporting underestimates the true prevalence of olfactory dysfunction [7, 8] . Despite this potential mechanism for epithelial injury, nasal cytological studies in 18 COVID-19 patients, of which 12 reported smell impairment, lacked typical findings of viral induced cellular injury [15] , suggesting that direct effects of the virus on the olfactory epithelium cannot likely account for the severity of loss seen in many patients.	./cache/cord-324041-lqokztor.txt	./txt/cord-324041-lqokztor.txt