id author title date pages extension mime words sentences flesch summary cache txt cord-325173-2jw15w28 Zhang, K. Causally Associations of Blood Lipids Levels with COVID-19 Risk: Mendelian Randomization Study 2020-07-07 .txt text/plain 3314 251 58 title: Causally Associations of Blood Lipids Levels with COVID-19 Risk: Mendelian Randomization Study Design: We performed two-sample Mendelian Randomization (MR) analyses to explore whether dyslipidemia, low density lipoprotein cholesterol (LDL-c), high density lipoprotein cholesterol (HDL-c), triglyceride (TG) and total cholesterol (TC) were causally related to COVID-19 risk and severity. If the difference Q − Qʹ is sufficiently extreme with respect to a χ2 distribution with the 1 degree of 114 freedom, we indicated that directional pleiotropy is an important factor and MR-Egger model provides 115 a better fit than the IVW method 20 CC-BY-NC-ND 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. This is the first study to characterize the potential causality of blood lipids for the susceptibility and 249 severity of COVID-19 using two-sample MR design rather than observational and perspective studies 250 based on conventional association analysis. ./cache/cord-325173-2jw15w28.txt ./txt/cord-325173-2jw15w28.txt