id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-326406-n0qi6gs8	Creed, Marina	Mild COVID-19 infection despite chronic B cell depletion in a patient with aquaporin-4-positive neuromyelitis Optica spectrum disorder.	2020-05-19		.txt	text/plain	1801	111	48	title: Mild COVID-19 infection despite chronic B cell depletion in a patient with aquaporin-4-positive neuromyelitis Optica spectrum disorder. Here, we report a 59-year-old woman with aquaporin-4-positive (AQPR4+) neuromyelitis Optica treated with rituximab who developed mild respiratory symptoms with COVID-19, despite B cell depletion at the time of infection. To infect the host, SARS-CoV-2 uses the viral receptors ACE2 and TMPRSS2, which are membrane associated proteins expressed in many cells throughout the body, particularly the respiratory system 2 . Most cases are mild, but in a number of patients, the disease evolves into an acute respiratory distress syndrome (ARDS) 3 or a dysregulated immune system state leading to cytokine storm, most often in older adults, requiring intensive care and resulting in increased mortality 4 . Here, we describe an AQPR4+ NMOSD patient treated with rituximab who developed mild COVID-19 infection despite B cell depletion.	./cache/cord-326406-n0qi6gs8.txt	./txt/cord-326406-n0qi6gs8.txt