id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-326687-9duu5bbz	Montastruc, Jean-Louis	Serious adverse drug reactions with hydroxychloroquine: a pharmacovigilance study in Vigibase®	2020-06-06		.txt	text/plain	844	64	49	The study was performed in Vigibase®, the WHO pharmacovigilance database, which registers all Individual Case Safety Reports (ICSRs) from more than 130 countries [5] . The 3 main SMQs were hypersensitivity/allergic reactions, arthralgia and gastrointestinal ADRs. Retinal toxicity was found in 6.7% of ICSRs, cardiac arrhythmias (including 1.6% torsades de pointes/QT prolongation) in 5.0%, cardiomyopathy in 3.3% (Table 1) . Although suffering from the mandatory biases of such studies (underreporting, lack of systematic information on doses and duration exposure in Vigibase®, denominator unknown, use of hydroxychloroquine in rheumatic or autoimmune disorders and not COVID-19), the results have several important strengths: data in the context of real world not studied in clinical trials, study performed in the world's largest pharmacovigilance database from around 130 countries allowing generalization of results. Off" label use of hydroxychloroquine , azithromycine, lopinavir-ritonavir and chloroquine in COVID-19: a survey of cardiac adverse drug reactions by the French Network of Pharmacovigilance Centers	./cache/cord-326687-9duu5bbz.txt	./txt/cord-326687-9duu5bbz.txt