id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-329863-r2vqsg5r	Salamanna, Francesca	Overt and non-overt disseminated intravascular coagulation and the potential role of heparin in the COVID-19 pandemic outbreak	2020-10-16		.txt	text/plain	2771	156	42	reviewing the data on coagulation abnormalities that occur in patients with COVID-19 suggested that this association is a consequence of the inflammatory response to SARS-CoV-2 infection that leads to thrombo-inflammation and drives thrombosis. 22, 23 The screening and diagnosis of non-overt DIC in patients with mild/moderate COVID-19 disease could be of key importance in order to optimize treatment and also prevent the organ failure representative of the most severe form of COVID-19. Since, as previously reported, COVID-19 is frequently complicated by coagulopathy and different forms of DIC can occur in patients, an active application of anticoagulants, such as low-molecular-weight heparin (LMWH), for patients with severe COVID-19 has been recommended by some expert consensus in China. Concerning the therapeutic use of LMWH in the presence of the most serious form of systemic activation of coagulation, DIC, or, more generally, for the treatment of specific hematological and/or clinical manifestation in patients with COVID-19, to date, there are still incomplete data and significant uncertainties with regard to safety.	./cache/cord-329863-r2vqsg5r.txt	./txt/cord-329863-r2vqsg5r.txt