id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-330887-q5i8lpan	Li, K.	The Dynamic Changes of Antibodies against SARS-CoV-2 during the Infection and Recovery of COVID-19	2020-05-21		.txt	text/plain	4021	214	54	By comprehensively analyzing the laboratory findings of 1,850 patients, we describe the dynamic changes of the total antibody, spike protein (S)-, receptor-binding domain (RBD)-, and nucleoprotein (N)specific IgM and IgG levels during SARS-CoV-2 infection and recovery. Our results indicate that the S-, RBD-, and Nspecific IgG generation of severe/critical COVID-19 patients is one week later than mild/moderate cases, while the levels of these antibodies are 1.5-fold higher in severe/critical patients during hospitalization (P<0.01). To explore the temporal dynamics of immune response after SARS-Cov-2 infection, we analyzed the antibody levels at different time points after symptoms onset, and the timing and level were compared between mild/moderate and severe/critical COVID-19 Results showed that total IgG, S-, RBD-, and N-specific IgG levels of the severe/critical COVID-19 patients were lower than that of the mild/moderate patients on admission, but these levels sharply increased during hospitalization and on discharge ( Figure 1 , Table 1 ).	./cache/cord-330887-q5i8lpan.txt	./txt/cord-330887-q5i8lpan.txt