id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-331604-jf6ybip5	Moratto, Daniele	Flow Cytometry Identifies Risk Factors and Dynamic Changes in Patients with COVID-19	2020-06-27		.txt	text/plain	1907	96	45	It has been recently shown that progression to severe and critical disease in patients with COVID-19 is associated with reduced expression of HLA-DR molecules on the surface of monocytes, and it has been speculated that this immune abnormality may underlie inadequate adaptive immune responses due to impaired SARS-CoV-2 antigen presentation [8] . Importantly, our results indicate that measurement of HLA-DR and CD4 mean fluorescent intensity (MFI) on the surface of monocytes at admission may not only distinguish patients with moderate versus those with severe disease but may also identify patients with severe phenotype who will progress to a critical status versus those who will improve and eventually recover (Fig. 1) . In particular, while progressive improvement in the counts of CD3 + , CD4 + , and CD8 + cells was observed in patients with moderate or severe disease who eventually recovered, those who progressed to a critical status remained with very low counts of all of these subsets, associated with markedly reduced expression of HLA-DR and CD4 molecules on the surface of monocytes ( Supplementary Fig. 2 ).	./cache/cord-331604-jf6ybip5.txt	./txt/cord-331604-jf6ybip5.txt