id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-332109-ont0tqpn	Wei, Yufeng	Substance Use Disorder in the COVID-19 Pandemic: A Systematic Review of Vulnerabilities and Complications	2020-07-18		.txt	text/plain	11728	668	39	The immunosuppression reduces antibody production, cytotoxicity, and T cell-mediated immune responses, and is linked to higher incidences of pathogen infections, slowed recovery, and severe disease progression in COVID-19. Due to compromised immune responses, cocaine abusers have considerably high incidences of viral infections, including human immunodeficiency virus (HIV), influenza, and potentially SARS-CoV-2. Cardiac arrhythmias and acute MI; oxygen imbalance; microvascular diseases and thrombosis [122] [123] [124] [125] [126] [127] [129] [130] [131] [132] Increased severity and mortality [12, 37, 38] Immune system Stimulating HPA axis; immunosuppression; defects in antibody formation, lymphocyte proliferation, macrophage and NK activation [141, 142] High incidence of viral infection [142] CNS Increased BBB permeability due to loss of tight junction proteins; rearrangement of cytoskeleton structure [143] [144] [145] [146] Endotheliitis and CNS infection [53, [55] [56] [57] Amphetamine, METH, MDMA	./cache/cord-332109-ont0tqpn.txt	./txt/cord-332109-ont0tqpn.txt