id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-333986-xkx181ek	Hall, Mary-Frances E.	Exercise for Older Adults Improves the Quality of Life in Parkinson’s Disease and Potentially Enhances the Immune Response to COVID-19	2020-09-06		.txt	text/plain	7074	360	40	title: Exercise for Older Adults Improves the Quality of Life in Parkinson's Disease and Potentially Enhances the Immune Response to COVID-19 We conclude that exercise, when correctly performed, improves QoL and outcomes in PwP, and that the enhanced immune response from moderate-intensity exercise could potentially offer additional protection against COVID-19. In contrast, many studies have shown that prolonged high-intensity aerobic exercise leads to increased death from a viral respiratory infection and over suppression of the immune response [51] [52] [53] . Two other studies investigating the neuroprotective effects of exercise in mice PD induction models collectively found in swimming [78] and endurance exercise [72] groups: (i) decreased levels of reactive oxygen species, (ii) significant reductions in α-Syn protein along with diminished pro-inflammatory cytokines (TNF-α and IL-β), and (iii) decreased activation of TLR2 and its subsequent downstream signaling cascades (MyD88, TRAF6, and TAK1) [72, 78] .	./cache/cord-333986-xkx181ek.txt	./txt/cord-333986-xkx181ek.txt