id author title date pages extension mime words sentences flesch summary cache txt cord-334360-bor30e5j Manganelli, Fiore Brainstem involvement and respiratory failure in COVID-19 2020-05-29 .txt text/plain 1019 67 50 Our data, though limited, indicate that brainstem involvement may play a role in respiratory failure and perhaps in the high death rate of COVID-19 patients. Under these premises, we evaluated three COVID-19 patients in ICU at Federico II Hospital in Naples that, although had recovered from pneumonia, could not be weaned from invasive mechanical ventilation due to depression of central respiratory drive. In conclusion, our data, though limited, indicate that brainstem involvement may play a role in respiratory failure [4] and perhaps in the high death rate of COVID-19 patients. Moreover, the weaning failure from mechanical ventilation due to central respiratory drive depression might underlie the unusual long stay in ICU reported for COVID-19 patients [2] . Moreover, the weaning failure from mechanical ventilation due to central respiratory drive depression might underlie the unusual long stay in ICU reported for COVID-19 patients [2] . ./cache/cord-334360-bor30e5j.txt ./txt/cord-334360-bor30e5j.txt