id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-334391-0172afa1	Gupta, Rahul	The double edged interferon riddle in COVID-19 pathogenesis	2020-11-01		.txt	text/plain	593	56	48	I would like to humbly add some views to it: there has been two varying reported type I interferon responses in COVID-19 pathogenesis [2] : one stating the suppression of host antiviral type I interferons (IFNs) and interferon stimulated genes (ISGs) and other stating increased expression of different ISGs, with further inductions of chemokines and cytokines [2] . The viral Nsps (particularly Nsp1) and the ORFs (particularly ORF 6) are known to antagonise the host antiviral IFNs initially by suppressing/delaying their expressions, leading to viral persistence and propagating inflammations. Hence, neither type I IFN nor type III IFN, which are known hard-wired for providing antiviral immunity, was activated in early stages of COVID-19. Aberrant production of NETs have been known to cause severe COVID-like pathophysiologies-thrombosis, lung damage, ARDS, multiorgan damage, etc. The initial type 1IFN suppression could lead to enhanced infiltration of neutrophils, NET formation and ensuing pathophysiologies.	./cache/cord-334391-0172afa1.txt	./txt/cord-334391-0172afa1.txt