id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-335037-4wj4p5ys	Annweiler, Cédric	Neurological, Cognitive, and Behavioral Disorders during COVID‐19: The Nitric Oxide Track	2020-06-24		.txt	text/plain	854	64	45	[3] [4] [5] Studies in experimental animals have well documented the synthesis of NO in the brain and its role in a variety of neuronal functions including learning and memory processes or locomotor activity. The production of NO is tightly linked to the renin-angiotensin system (RAS), precisely targeted by SARS-CoV-2 7 that was described to overactivate the RAS by interacting, via its spike (S) glycoprotein, with the metallopeptidase angiotensinconverting enzyme 2 (ACE2) receptor, 7 expressed at the surface of numerous cell types including cerebral neurons. 8 In RAS, angiotensin II, by acting on the vasoconstrictor type 1 angiotensin II receptor (AT 1 R), reportedly diminishes the production of NO, 9 leading to an expected decrease in NO concentrations in the brain during COVID-19, which needs to be compensated to prevent neurological cognitive and behavioral disorders. 10 All these molecules are expected to counteract the SARS-CoV-2-induced overactivation of RAS, to maintain NO production, and to reverse, to some extent, the associated neurological cognitive and behavioral disorders in COVID-19.	./cache/cord-335037-4wj4p5ys.txt	./txt/cord-335037-4wj4p5ys.txt