id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-335138-37czoiq8	Booz, George W.	Macrophage responses associated with COVID-19: A pharmacological perspective	2020-09-11		.txt	text/plain	774	63	42	The pandemic is the result of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has demonstrated high rates of infectivity leading to great morbidity and mortality in vulnerable populations. In the case of COVID-19, the cytokine storm often fits the pattern of the macrophage activation syndrome with lymphocytopenia. The basis for the imbalance between the innate and adaptive immune systems is not clearly defined, but highlights the effect of SARS-CoV-2 on macrophages. Here we discuss the potential underlying basis for the impact of SARS-CoV-2 on macrophages, both direct and indirect, and potential therapeutic targets. A better understanding of the molecular consequences of SARS-CoV-2 infection of macrophages could lead to novel and more effective treatments for COVID-19. Cytokine storm and leukocyte changes in 677 mild versus severe SARS-CoV-2 infection: Review of 3939 COVID-19 patients in China 678 and emerging pathogenesis and therapy concepts	./cache/cord-335138-37czoiq8.txt	./txt/cord-335138-37czoiq8.txt