id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-335386-eflyypev	Steinman, Jonathan Baruch	Reduced development of COVID-19 in children reveals molecular checkpoints gating pathogenesis illuminating potential therapeutics	2020-10-06		.txt	text/plain	5373	287	48	Exploring why the pediatric population is generally far less likely to develop COVID-19, even though their rate of infection is similar to adults (10), may offer productive clues, enabling strategies for (1) Coronavirus associated with common colds in children may offer some protection due to cross-reactive T cell immunity and crossreactive antibody immunity between common coronaviruses and SARS-CoV-2, and due to reduced ACE2 in nasal mucosa of children. A reasonable conjecture might be that, if ACE2 and/or TMPRSS2 expression is diminished in children, then viral infection of respiratory cells by SARS-CoV-2 might be less likely at any given viral load, and, additionally, there might be reduced expression of associated inflammatory modules. T[h]2 inflammation may predispose individuals to experience better COVID-19 outcomes through a decrease in airway levels of ACE2 that override any countervailing effect from increased expression of TMPRSS2." It is indeed surprising that the Th2 immune type associated with allergic diseases including asthma, and with eosinophilia, provides some protection to COVID-19 in children.	./cache/cord-335386-eflyypev.txt	./txt/cord-335386-eflyypev.txt