id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-335610-3v8140b6	Prasanth, D. S. N. B. K.	In silico identification of potential inhibitors from Cinnamon against main protease and spike glycoprotein of SARS CoV-2	2020-06-22		.txt	text/plain	5031	310	49	Our research study is intended to recognize the phyto-derived antiviral substances from Cinnamon against COVID-19 main protease enzyme and to understand the in silico molecular basis of its activity. Based on the above properties of Cinnamon, this research aimed to show a variety of active compounds across all Cinnamon varities and decide whether and how they interact with proteins i.e. main protease (Joshi et al., 2020) and spike protein, that are essential in the management of SARS-CoV-2. The crystal structure of Main protease (6LU7) and Spike receptor-binding domain complexed with its receptor ACE2 (6LZG) with selected top ligands identified from docking analysis such as Tenufolin (TEN) and Pavetannin C1 (PAV) were subjected to molecular dynamics using gromacs GPU enabled package. The main protease with tenufolin Spike protein (6LZG), associated with SARS was found to exhibit the best possible interaction with Pavetannin C1 (À11.1 kcal/mol) among the phytochemicals ( Table 2) .	./cache/cord-335610-3v8140b6.txt	./txt/cord-335610-3v8140b6.txt