id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-335733-u1g03s2y	Lakshmanan, Hari Hara Sudhan	Design of a Microfluidic Bleeding Chip to Evaluate Antithrombotic Agents for Use in COVID-19 Patients	2020-08-06		.txt	text/plain	3488	191	43	Since limited in vitro methods exist for assessing the effects of anticoagulants on hemostasis, the development of novel therapies to safely prevent thrombosis in COVID-19 patients relies on preclinical animal models and early phase human trials. METHODS: The design of the microfluidic device consists of two orthogonal channels: an inlet that serves as a model blood vessel, and a bleeding channel to model hemostatic plug formation at sites of compromised endothelial barrier function. RESULTS: Perfusion of human whole blood through the microfluidic bleeding chip led to initial platelet adhesion and aggregation at the pillars followed by hemostatic plug formation and occlusion of the bleeding channel. While the most clinically relevant conclusions regarding the safety of anticoagulants will ultimately be learned through clinical trials, in vitro models hold potential usefulness in revealing early safety and efficacy signals to guide future anticoagulant development of agents to prevent thrombosis in COV-ID-19 patients without compromising hemostasis.	./cache/cord-335733-u1g03s2y.txt	./txt/cord-335733-u1g03s2y.txt