id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-336163-7xqmuoye	van Dongen, Christel MP	Unusually Rapid Development of Pulmonary Hypertension and Right Ventricular Failure after COVID-19 Pneumonia	2020-06-17		.txt	text/plain	1220	69	35	COVID-19 infection is increasingly being associated with systemic and multi-organ involvement, encompassing cytokine release syndrome and thromboembolic, vascular and cardiac events. The patient described experienced unusually rapid development of pulmonary hypertension (PH) and right ventricular failure after recent severe COVID-19 pneumonia with cytokine release syndrome, which initially was successfully treated with methylprednisolone and tocilizumab. Patients with severe COVID-19 pneumonia and concomitant cytokine release syndrome may be particularly at risk for the development of secondary pulmonary hypertension and right ventricular failure. This case report describes a patient with unusually rapid development of life-threatening pulmonary hypertension (PH) following earlier hospitalisation and successful treatment for severe CRS caused by COVID-19 infection. In view of the association of COVID-19 with coagulopathy and microvascular disease, subsequent potential micro-PE as well as interstitial pulmonary damage, PH is likely to be a frequent complication of severe COVID-19 pneumonia and CRS. COVID-19 is a pulmonary viral infection which can result in severe systemic, multi-organ disease in some patients.	./cache/cord-336163-7xqmuoye.txt	./txt/cord-336163-7xqmuoye.txt