id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-336702-2qa4u8gv	Agarwal, Sangya	Harnessing CAR T-cell Insights to Develop Treatments for Hyperinflammatory Responses in Patients with COVID-19	2020-04-17		.txt	text/plain	2364	124	44	Consistent with HLH, accumulations of macrophages are found in the lungs of patients with COVID-19 ( 9 ) , and HLH has previously been reported in patients with SARS, MERS, and other severe systemic viral infections. Drug treatments used for HLH/MAS and ARDS may also be effective in treating patients with COVID-19. Thus, an urgent need emerges to uncover therapies that may be effective for patients with SARS-CoV-2 infection. Thus, if properly timed in patients after exposure to virus, CSA could serve as a broad-spectrum inhibitor to control SARS-CoV-2 infection and decrease the magnitude of cytokine release. This shows not only the coincidence of treatments that modulate dysfunctional host immune responses, but also the potential complications with overlapping SARS-CoV-2 infections and cancer immunotherapies. This is important because comorbidities from CRS due to CAR T-cell therapy and HLH-like symptoms due to SARS-CoV 2 infection could be fatal.	./cache/cord-336702-2qa4u8gv.txt	./txt/cord-336702-2qa4u8gv.txt