id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-337082-2xas41mj	Akoumianakis, Ioannis	The renin–angiotensin–aldosterone system as a link between obesity and coronavirus disease 2019 severity	2020-06-22		.txt	text/plain	3524	245	40	2 Interestingly, the aetiologic agent behind COVID-19, severe acute respiratory distress coronavirus 2 (SARS-CoV2), interacts with angiotensin-converting enzyme 2 (ACE2), a part of the renin-angiotensin-aldosterone (RAAS) axis, suggesting therapeutic implications for this axis. ACE2 is expressed in both alveolar cells and cardiomyocytes, which may explain the severe lung and myocardial injury observed in COVID-19 patients. 97 Considering the detrimental effects of AngII on lung and myocardial biology, it has been hypothesized that ACE1 inhibitors and ARBs may actually protect against severe COVID-19 disease. 33 A retrospective study in hypertensive patients with COVID-19 showed that in-hospital use of ACE1 inhibitors and ARBs was, in fact, associated with reduced mortality. The renin-angiotensin-aldosterone (RAAS) axis as a link between obesity and coronavirus disease 2019 (COVID-19) severity. The link between adipose tissue renin-angiotensin-aldosterone system signaling and obesity-associated hypertension A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury The renin-angiotensin-aldosterone system as a link between obesity and coronavirus disease 2019 severity	./cache/cord-337082-2xas41mj.txt	./txt/cord-337082-2xas41mj.txt