id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-337248-thzox29o	Tsolaki, Vasiliki	Right ventricular dilation: The additive effect of mechanical ventilation on pulmonary embolism in Covid-19 patients	2020-08-04		.txt	text/plain	978	50	38	We read with great interest the study of van Dam et al presenting the radiographic characteristics of 23 patients with Covid-19 acute Pulmonary Embolism (PE) and right ventricular (RV) dilation. Van Dam's paper confirms the increased incidence of thrombotic events in patients, as in the majority of the presented cohort, PE was an unexpected finding; the reasons for ordering a computed tomography pulmonary angiography (CTPA) were not indicative of PE presence [lack of clinical improvement after mechanical ventilation initiation and fever (61.3%)]. Moreover, PEEP effects may be rather exacerbated in the setting of nonrecruitable lung regions, as in cases of focal but also in non-focal lung involvement, J o u r n a l P r e -p r o o f when extensive, multilobar ground glass opacifications are present (as in Figure 1 in van Dam's study) [1, 9] ; increased PEEP levels, when not resulting in lung recruitment, may induce dead space ventilation and compression of the pulmonary vasculature, leading to increased pulmonary vascular resistance (PVR) and RV dilation and dysfunction.	./cache/cord-337248-thzox29o.txt	./txt/cord-337248-thzox29o.txt