id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-337627-1a2gpqdl	Alvarado-Vasquez, Noé	Could a family history of type 2 diabetes be a risk factor to the endothelial damage in the patient with COVID-19?	2020-11-06		.txt	text/plain	2325	116	47	Previous evidence has shown the presence of early endothelial dysfunction in healthy subjects but with a family history of type 2 diabetes (FH-DM2), where glucose metabolism, the synthesis of nitric oxide (NO), reactive oxygen species (ROS), as well as expression of genes involved with their synthesis are impaired. Therefore, we hypothesized that an FH-DM2 should be considered an important risk factor, since the individuals with this background develop an early endothelial dysfunction, which would increase the susceptibility and severity of infection and damage to the endothelium, in the patient infected with the SARS-CoV-2. For example, in a representative percentage of patients with COVID-19, pathologies such as cardiovascular disease or diabetes mellitus, which could be associated with an early endothelial dysfunction, have not been reported. Based on the above, we hypothesized that a family history of type 2 diabetes (FH-DM2) could be a risk factor for the severe endothelial damage observed in the patient infected with SARS-CoV-2.	./cache/cord-337627-1a2gpqdl.txt	./txt/cord-337627-1a2gpqdl.txt