id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-338951-wu1ofih9	Sestili, Piero	Paracetamol-Induced Glutathione Consumption: Is There a Link With Severe COVID-19 Illness?	2020-10-07		.txt	text/plain	4664	230	45	However, a warning from some research reports and National Authorities raised NSAIDs safety concerns because of the supposed induction of angiotensin-converting enzyme 2 (ACE2) levels (the receptor used by SARS-CoV2 to enter host airways cells), the increased risk of bacterial superinfections and masking of disease symptoms. This warning was grounded on a wide number of studies reviewed in (Micallef et al., 2020b) including a recent report of the French Pharmacovigilance Network conducted in 2019 (Crpv De Tours, CRPV de Marseille, 2019) showing that the use of NSAIDs (even if given for short times and/or associated to antibiotics) for the treatment of fever and nonrheumatic pain (which may be indicative of an underlying infection) increases the risk of severe bacterial complications, particularly of the lungs, and on the supposed ibuprofen-induced A angiotensin-converting enzyme 2 (ACE2) overexpression.	./cache/cord-338951-wu1ofih9.txt	./txt/cord-338951-wu1ofih9.txt