id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-340010-t1m7dxzc	Schaefer, Esperance A. K.	Interrelationship Between Coronavirus Infection and Liver Disease	2020-05-21		.txt	text/plain	1416	97	43	Several published studies have characterized the frequency and severity of liver biochemistry abnormalities on presentation, and a few have determined whether these abnormalities are associated with increased disease-related morbidity or death, as summarized in Table 1 . 9, 10, [12] [13] [14] [16] [17] [18] [19] [20] [21] [22] [23] [24] The largest published study to date encompassed 5700 hospitalized patients in New York and examined admission serologies: aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were both frequently elevated (58.4% and 39.0% of subjects, respectively), and a separate large cohort found elevations to be more common in severe disease. 28 Thus, the liver injury observed in COVID-19 may reflect a direct viral effect, but other potential contributors must be considered, both at the time of initial presentation and during disease progression and management. Hepatic injury from SARS-CoV2 infection is observed from the time of initial contact with the medical system, suggesting that the primary insult is unrelated to medical management but rather due to either direct effect of the virus or a consequence of the systemic disease.	./cache/cord-340010-t1m7dxzc.txt	./txt/cord-340010-t1m7dxzc.txt