id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-341529-dmiy0l9c	Siniscalchi, Antonio	Could COVID-19 represent a negative prognostic factor in patients with stroke?	2020-04-20		.txt	text/plain	635	43	49	Thus, they may be a potential target of SARS-CoV-2, which might explain the death of olfactory cells in patients with COVID-19. The spread of SARS-CoV-2 through the cribriform plaque of the ethmoid bone during an initial or subsequent infection phase can lead to brain involvement. The presence of CoVs in the cerebral nervous system has been confirmed in the cerebrospinal fluid and brain tissues of patients during autopsies. In patients with stroke, the presence of COVID-19 could be a potential extrinsic factor in the genesis or worsening of stroke. [8] [9] [10] The onset or worsening of a stroke in these patients could be caused either by direct damage of the CoVs on the nervous system and/or by an activation of the mechanisms of COVID-19 inflammation induced as well coagulation disorders. As the disease spreads and new evidence emerges, we need to identify the existence of additional pathophysiological mechanisms of stroke in COVID-19 patients. Possible central nervous system infection by SARS coronavirus	./cache/cord-341529-dmiy0l9c.txt	./txt/cord-341529-dmiy0l9c.txt