id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-341783-e7xz4utr	Vistisen, Simon T.	Risk and prognosis of COVID-19 in patients treated with renin–angiotensin–aldosterone inhibitors	2020-07-06		.txt	text/plain	1907	99	47	2 Because ACE2 plays an important role in the renin-angiotensin system and also acts as a receptor for SARS-CoV-2 cell entry, hypotheses about an association between ACEi/ARBs and COVID-19 outcomes were rapidly generated. Nevertheless, based on these initial observational findings, there seems to be no increased risk of SARS-CoV-2 infection for ACEi/ARB users. Four studies examined the prognosis of COVID-19 patients and uniformly found that risk of severe outcomes was not higher for the collapsed group of ACEi and ARB 740 Vistisen et al. The transmembrane angiotensin-converting enzyme 2 receptor allows SARS-CoV-2 entry and leads to virus replication, activation of innate immune system/complement, cytokine formation followed by neutrophils/lymphocytes in the lung and development of acute respiratory distress syndrome (ARDS). Association of renin-angiotensin system inhibitors with severity or risk of death in patients with hypertension hospitalized for coronavirus disease 2019 (COVID-19) infection in Wuhan, China	./cache/cord-341783-e7xz4utr.txt	./txt/cord-341783-e7xz4utr.txt