id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-342059-y3zlyy1z	von der Thüsen, Jan H.	Case report: a fatal combination of hemophagocytic lymphohistiocytosis with extensive pulmonary microvascular damage in COVID-19 pneumonia	2020-10-23		.txt	text/plain	1940	99	37	Here we present a case with histopathological evidence for hemophagocytic lymphohistiocytosis (HLH) and extensive concurrent microvascular damage in fatal COVID-19 pneumonia and speculate on the cooccurrence of these serious complications of SARS-CoV-2 infection. At autopsy, bilaterally enlarged lungs were seen, with upon microscopy in the lung tissue extensive vascular changes including bilateral and diffuse edema and intra-alveolar fibrinous aggregates with an acute fibrinous and organizing pneumonia (AFOP) pattern (Fig. 1a) , related to multiple associated foci of microvascular damage with hyaline thrombi (Fig. 1b and c) . This case demonstrates histopathological evidence of HLH in fatal COVID-19 pneumonia with a concurrent severe microvascular damage pattern in both lungs, with capillary thrombosis and extensive intra-alveolar fibrin exudation with an AFOP pattern. A sudden demise in Fig. 1 Histopathological features of microvascular damage with acute fibrinous and organizing pneumonia (AFOP) and hemophagocytic lymphohistiocytosis in a case of fatal COVID-19 pneumonia.	./cache/cord-342059-y3zlyy1z.txt	./txt/cord-342059-y3zlyy1z.txt