id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-342857-vj6sw2ne	McCullough, Peter A.	Pathophysiological Basis and Rationale for Early Outpatient Treatment of SARS-CoV-2 (COVID-19) Infection	2020-08-07		.txt	text/plain	2215	120	39	In the absence of clinical trial results, physicians must use what has been learned about the pathophysiology of SARS-CoV-2 infection in determining early outpatient treatment of the illness with the aim of preventing hospitalization or death. Thus, in the context of present knowledge, given the severity of the outcomes and the relative availability, cost, and toxicity of the therapy, each physician and patient must make a choice: watchful waiting in self-quarantine or empiric treatment with the aim of reducing hospitalization and death. (10) For the ambulatory patient with recognized early signs and symptoms of COVID-19, often with nasal real-time reverse transcription or oral antigen testing pending, the following four principles could be deployed in a layered and escalating manner depending on clinical manifestations of COVID-19 like illness(11) and confirmed infection: 1) reduction of reinoculation, 2) combination antiviral therapy, 3) immunomodulation, 4) antiplatelet/antithrombotic therapy.	./cache/cord-342857-vj6sw2ne.txt	./txt/cord-342857-vj6sw2ne.txt