id author title date pages extension mime words sentences flesch summary cache txt cord-343449-4uxwojzo The Gibraltar COVID-19 Research Group Health Systems, Oxygen and mortality in COVID-19 pneumonia: a comparative analysis of supplemental oxygen policies and health outcomes across 26 countries. 2020-07-04 .txt text/plain 3912 217 48 Methods Three independent investigators searched for, identified and extracted the nationally recommended target oxygen levels for the commencement of oxygen in COVID-19 pneumonia from the 29 worst affected countries. We then applied linear regression analysis to examine for potential association between national targets for the commencement of oxygen and case fatality rates. Whilst none of the studies analysed in the IOTA metaanalysis related to pneumonia, and the majority of studies examined oxygen as a treatment not as a means to correct hypoxia, the authors suggest optimal target SpO2 for all acute medical patients might be 94-96% [12] . In this situation, where the national guideline target SpO2 is part of an overall strategy of avoiding admissions, then whilst it does remain likely conservative oxygen approaches do contribute to higher mortality, there may also be contribution of other policies. There is clear disparity between national guidelines for target oxygen saturations (SpO2) in COVID-19 across the countries analysed here, and such disparity is associated with national case fatality rates (CFR). ./cache/cord-343449-4uxwojzo.txt ./txt/cord-343449-4uxwojzo.txt