id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-343766-hlg7t5i5	Vinken, Mathieu	A putative AOP for pneumonia related to COVID-19	2020-07-20		.txt	text/plain	994	59	47	In order to further encourage research in this direction, an updated version of the putative AOP for pneumonia linked to COVID-19 is proposed, which encompasses new knowledge that is rapidly accumulating (Fig. 1) . One of the major MIEs in this AOP is the binding of SARS-CoV-2 to the angiotensin-converting enzyme 2 (ACE2) receptor at the plasma membrane surface of type II pneumocytes lining the alveoli in lung. Such AOP network should comprise the mechanisms driving the multi-organ failure frequently observed in severe COVID-19 patients, for which the causes (i.e. MIEs) are as yet not entirely clear or delineated. Thus, liver failure may be caused by the direct binding and actions of SARS-CoV-2 in hepatocytes or cholangiocytes, but could also be an indirect consequence of the systemic inflammatory response syndrome associated with COVID-19. A putative AOP for pneumonia linked to COVID-19	./cache/cord-343766-hlg7t5i5.txt	./txt/cord-343766-hlg7t5i5.txt