id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-344382-vge4ho2v	De Flora, Silvio	Rationale for the use of N‐acetylcysteine in both prevention and adjuvant therapy of COVID‐19	2020-08-11		.txt	text/plain	4995	271	41	5 Elderly individuals maintain a chronic low level of inflammation that is associated with oxidative stress and inflammatory cytokine production, a condition that increases the severity of viral infections in this population and that could be attenuated by administration of antioxidants. 36 A randomized, double-blind, placebo-controlled, prospective clinical trial in 5 ICUs in the USA and Canada showed that the intravenous administration of NAC (70 mg/ kg body weight), every 8 hours for 10 days, effectively repleted GSH in red blood cells, decreased the number of days of acute lung injury, and significantly increased the cardiac index. 50 NAC inhibited the pulmonary inflammation and edema as well as myeloperoxidase (MPO) activity, total cells, neutrophils, macrophages, TNF-α, IL-6, IL-1β, and chemokine (C-X-C motif) ligand-10 (CXCL-10) in the bronchoalveolar lavage fluid and reduced the levels of toll-like receptor 4 (TLR4) protein and mRNA in the lungs of BALB/c mice inoculated intranasally with A/swine/HeBei/012/2008/ H9N2 influenza virus.	./cache/cord-344382-vge4ho2v.txt	./txt/cord-344382-vge4ho2v.txt