id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-345730-bxwsup70	Kočar, Eva	Cholesterol, lipoproteins, and COVID-19: basic concepts and clinical applications	2020-11-04		.txt	text/plain	4028	221	40	In vitro depletion of membrane-bound cholesterol from Angiotensin-Converting Enzyme 2 (ACE2)-expressing cells led to a reduced infectivity of CoVs, since the binding of the spike protein was reduced by half [44] . By participating in cholesterol outflow from the cell membrane to HDL particles, PON1 contributes to lowering the cholesterol levels within lipid rafts, thus modulating viral infection (Fig. 1c) . Therefore, it is intriguing to contemplate whether NAFLD patients without treatment are more J o u r n a l P r e -p r o o f susceptible for SARS-CoV-2 infection, or whether statin application may directly affect the entry of SARS-CoV-2 into the host cell by regulating cholesterol cell levels. As lipid lowering drugs, statins might thus significantly reduce the attachment and internalization of SARS-CoV-2 by lowering membrane cholesterol levels (Fig. 1c ) [37] .	./cache/cord-345730-bxwsup70.txt	./txt/cord-345730-bxwsup70.txt