id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-345879-nbfg47x5	Bonaz, Bruno	Targeting the cholinergic anti-inflammatory pathway with vagus nerve stimulation in patients with Covid-19?	2020-07-29		.txt	text/plain	4072	213	44	title: Targeting the cholinergic anti-inflammatory pathway with vagus nerve stimulation in patients with Covid-19? We hypothesize that this cytokine storm and the worsening of patients' health status can be dampened or even prevented by specifically targeting the vagal-driven cholinergic anti-inflammatory pathway (CAP). Hence, targeting the α7nAChRs through vagus nerve stimulation (VNS) could be of interest in the management of patients with SARS-CoV-2 infection. Indeed, through the wide innervation of the organism by the vagus nerve, especially the lungs and gastrointestinal tract, VNS appears as a serious candidate for a few side effect treatment that could dampen or prevent the cytokine storm observed in COVID-19 patients with severe symptoms. Indeed, a septic shock-induced increase of TNF in the liver and the blood in mice was dampened by stimulation of the distal end cut of the vagus nerve thus arguing for an anti-inflammatory effect of vagal efferents which release acetylcholine (ACh) (Borovikova et al.	./cache/cord-345879-nbfg47x5.txt	./txt/cord-345879-nbfg47x5.txt