id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-347030-yx3j6373	Cao, Xuetao	COVID-19: immunopathology and its implications for therapy	2020-04-09		.txt	text/plain	1519	74	35	Most patients with COVID-19 exhibit mild to moderate symptoms, but approximately 15% progress to severe pneumonia and about 5% eventually develop acute respiratory distress syndrome (ARDS), septic shock and/or multiple organ failure 1, 2 . Convalescent plasma containing neutralizing antibodies has been used to treat a small number of patients with severe disease, and preliminary results show clinical improvement in 5 of 5 critically ill patients with COVID-19 who developed ARDS 8 . High levels of pro-inflammatory cytokines may lead to shock and tissue damage in the heart, liver and kidney, as well as respiratory failure COVID-19: immunopathology and its implications for therapy Xuetao Cao 1, 2 Severe coronavirus disease 2019 (COVID-19) is characterized by pneumonia, lymphopenia, exhausted lymphocytes and a cytokine storm. In addition to the cytokine-based pathology in patients with severe COVID-19, complement activation has also been observed, indicating that complement inhibitors, if used at an early stage of the infection, may attenuate the inflammatory damage.	./cache/cord-347030-yx3j6373.txt	./txt/cord-347030-yx3j6373.txt