id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-347058-kejcwlng	Akbari, Hamed	The role of cytokine profile and lymphocyte subsets in the severity of coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis	2020-07-29		.txt	text/plain	3255	180	48	AIMS: This study aimed to make a comparison between the clinical laboratory-related factors, complete blood count (CBC) indices, cytokines, and lymphocyte subsets in order to distinguish severe coronavirus disease 2019 (COVID-19) cases from the non-severe ones. Our meta-analyses with random-effect models showed a significant decrease in lymphocytes, monocyte, CD4+ T cells, CD8+ T cells, CD3 cells, CD19 cells, and natural killer (NK) cells and an increase in the white blood cell (WBC), neutrophils, neutrophil to lymphocyte ratio (NLR), C-reactive protein (CRP)/hs-CRP, erythrocyte sedimentation rate (ESR), ferritin, procalcitonin (PCT), and serum amyloid A (SAA), interleukin-2 (IL-2), IL-2R, IL-4, IL-6, IL-8, IL-10, tumor necrosis factor-alpha (TNF-α), and interferon-gamma (INF-γ) in the severe group compared to the non-severe group. In this new pandemic pneumonia, the levels of CRP and ESR significantly increased in severe cases compared to non-severe COVID-19 patients [31, 45] , which greatly coincides with those found in the present systematic review and meta-analysis.	./cache/cord-347058-kejcwlng.txt	./txt/cord-347058-kejcwlng.txt