id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-347547-makm0j09	Duran-Frigola, Miquel	Bioactivity Profile Similarities to Expand the Repertoire of COVID-19 Drugs	2020-07-16		.txt	text/plain	1942	99	46	By comparing the set of drugs reported to be potentially active against SARS-CoV-2 to a universe of 1 million bioactive molecules, we identify compounds that display analogous chemical and functional features to the current COVID-19 candidates. Searches can be filtered by level of evidence and mechanism of action, and results can be restricted to drug molecules or include the much broader space of bioactive compounds. Indeed, we conducted a limited review of the most relevant scientific literature and identified over 200 compounds that are potentially active against COVID-19 with different levels of experimental support, from purely computational predictions to preclinical and drugs already in clinical trials. We use the list of COVID-19 compounds extracted from the literature, with different levels of experimental evidence, as bait to search for compounds with similar bioactivity or chemical features among the 800,000 molecules contained in the CC.	./cache/cord-347547-makm0j09.txt	./txt/cord-347547-makm0j09.txt