id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-347553-d7q6u7vj	Criado, Paulo Ricardo	Lessons from dermatology about inflammatory responses in Covid‐19	2020-07-12		.txt	text/plain	5067	326	40	The antithrombotic effect of chloroquine analogues has been attributed to a range of mechanisms, including reduction in red blood cell aggregation, inhibition of platelet aggregation and adhesion, reduction in blood viscosity and enhancement of antiplatelet activity 86 Hydroxychloroquine and chloroquine were indicated for treat patients with COVID-19, under in vitro effects due to capacity as 87 : (a) an inhibitor of endocytic pathways through an elevation of endosomal pH, and (b) these drugs shown to interfere with the terminal glycosylation of angiotensin-converting enzyme-2 (ACE2), which acts as a plasma membrane receptor for both SARS-CoV and SARS-CoV-2. 61 99 Procoagulant factors, such F I G U R E 5 Clinical outcomes in SARS-CoV-2 infected patients/Covid-19, immune system responses, systemic and possible cutaneous manifestations.① The outcome spectrum is probably related to intrinsic host factors. ③ In a selected group of patients, with moderate and severe Covid-19, some authors proposed that a genetic background in these subjects might determinate one new immune response as ④ 'second wave' of cytokines production, the 'CSS' in response to the SARS-CoV-2 infection, similar to Macrophage Activation Syndrome (MAS-like/sHLH).	./cache/cord-347553-d7q6u7vj.txt	./txt/cord-347553-d7q6u7vj.txt