id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-347737-guldy3cq	Dalan, Rinkoo	Metformin, Neutrophils and COVID-19 Infection	2020-05-22		.txt	text/plain	698	55	38	Recent reports have shown that that sera from patients with COVID-19 have elevated levels of NETS such as cell-free DNA, myeloperoxidase(MPO)-DNA, and citrullinated histone H3 (Cit-H3), highly specific markers of NETs and these were associated with markers of inflammation [10] . Metformin has been shown to reduce neutrophil count in polycystic ovarian disease [13] and reduce neutrophil lymphocyte ratio in patients with diabetes [14] . Metformin has been associated with a decrease in neutrophil gelatinase-associated lipocalin (NGAL), an acute phase protein released by neutrophils and is known to be elevated in patients with diabetes [17] . While beneficial mechanistic links through neutrophils can be suggested with the use of metformin, it is important to realise that a relatively high rate of mortality in patients with co-existing diabetes has been reported in COVID-19 [20] . Neutrophil gelatinase associated lipocalin (NGAL) is elevated in type 2 diabetics with carotid artery stenosis and reduced under metformin treatment.	./cache/cord-347737-guldy3cq.txt	./txt/cord-347737-guldy3cq.txt