id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-348365-e90544er	Alharthy, Abdulrahman	Lung Injury in COVID-19—An Emerging Hypothesis	2020-07-24		.txt	text/plain	1401	102	41	We have recently shown that patients with life-threatening SARS-CoV-2 disease (COVID-19) had associated cytokine release syndrome (CRS) 1 as outlined in Table 1 . 5, 6 However, in a recent series, patients with severe COVID-19 have demonstrated features of acute disseminated encephalomyelitis (ADEM) with hemorrhagic changes, 7 which has not been related to the severity of lung involvement, and it has been partially attributed to diffuse endothelial dysfunction related to the viral binding to the ACE-2 receptors. 8, 9 However, neurogenic pulmonary edema could indeed occur in patients with severe COVID-19 pneumonia although it should not be characterized as a form of ARDS, but rather as a noncardiogenic interstitial lung edema with peripheral lung zone distribution, which could be observed in viral pneumonitis and after brain injury. The versatility of clinical features such as cardiac dysfunction, thromboembolic disease, and neurological manifestations along with the lung injury, and other systemic sequelae of SARS-CoV-2 infection may represent an evolving clinical syndrome, which requires further studying and analysis.	./cache/cord-348365-e90544er.txt	./txt/cord-348365-e90544er.txt