id author title date pages extension mime words sentences flesch summary cache txt cord-351917-0lcjskjf Li, S. Modifiable lifestyle factors and severe COVID-19 risk: Evidence from Mendelian randomization analysis 2020-10-21 .txt text/plain 2169 124 45 Methods Genome-wide significant genetic variants associated with body mass index (BMI), lifetime smoking, alcohol consumption and physical activity identified by large-scale genome-wide association studies (GWAS) were selected as instrumental variables. The Centre for Disease Control and Prevention of US suggests that people with obesity and smoking are at increased risk of COVID-19 severe illness 6 Mendelian randomization (MR) uses exposure-associated genetic variants as instrumental variables to assess the causality between exposures and outcomes 7 . preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in Sensitivity analyses were performed using MR-Egger regression 17 , weighted median method 18 and weighted mode method 19 , which relax some MR assumptions and allow some genetic instrumental variables to be invalid, but are less powerful than IVW method. ./cache/cord-351917-0lcjskjf.txt ./txt/cord-351917-0lcjskjf.txt