id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-352526-t8odetzw	Pinto, Bruna G G	ACE2 Expression is Increased in the Lungs of Patients with Comorbidities Associated with Severe COVID-19	2020-06-11		.txt	text/plain	3032	199	50	Although angiotensin-converting enzyme 2 (ACE2) is crucial for SARS-CoV2 to bind and enter host cells, no study has systematically assessed the ACE2 expression in the lungs of patients with these diseases. Here, we analyzed over 700 lung transcriptome samples of patients with comorbidities associated with severe COVID-19 and found that ACE2 was highly expressed in these patients, compared to control individuals. Correlation and network analyses revealed many potential regulators of ACE2 in the human lung, including genes related to histone modifications, such as HAT1, HDAC2, and KDM5B. The molecular mechanism responsible for the increased disease severity in patients with these comorbidities is not fully understood, but previous studies suggest a role for angiotensin-converting enzyme 2 (ACE2) (5) . Here, we showed that the expression of the gene encoding the ACE2 receptor in lung tissue is upregulated by diseases representing comorbidities along with COVID-19.	./cache/cord-352526-t8odetzw.txt	./txt/cord-352526-t8odetzw.txt