id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-353283-rlvfk8w8	Liu, D.	Pleotropic association between risk and prognosis of COVID-19 and gene expression in blood and lung: A Mendelian randomization analysis	2020-09-03		.txt	text/plain	3218	213	52	Pervious genome-wide association studies (GWAS) have identified potential genetic factors involved in the risk and prognosis of COVID-19, but the underlying biological interpretation remains largely unclear. Methods: We applied the summary data-based Mendelian randomization (SMR) method to identify genes that were pleiotropically/potentially causally associated with the risk and various outcomes of COVID-19, including severe respiratory confirmed COVID-19 and hospitalized COVID-19. In this paper, we applied the summary data-based MR (SMR) method integrating summarized GWAS data for COVID-19 and cis-eQTL (expression quantitative trait loci) data to prioritize genes that are pleiotropically/potentially causally associated with the risk and prognosis of COVID-19. In the present study, we integrated GWAS and eQTL data in the MR analysis to explore putative genes that showed pleiotropic/potentially causal association the susceptibility/prognosis of COVID-19. We only performed analyses using blood and lung eQTL data, more studies are needed to explore tissueand cell-type-specific genes involved in the host responses to COVID-19 infection.	./cache/cord-353283-rlvfk8w8.txt	./txt/cord-353283-rlvfk8w8.txt