id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-354389-l2erwez8	Street, Maria Elisabeth	HMGB1: A Possible Crucial Therapeutic Target for COVID-19?	2020-05-06		.txt	text/plain	1426	79	44	Autophagy is one of the mechanisms involved in COVID-19 and is involved in viral entry and replication in cells, so targeting this pro-Street Horm Res Paediatr 2 DOI: 10.1159/000508291 cess has been suggested as a possible novel therapeutic strategy for COVID-19 [12] . Finally, my research group previously showed that cystic fibrosis transductance regulator (CFTR) malfunction, as found in cystic fibrosis, increases HMGB1 serum concentrations, along with inflammation, and further increases are observed at the onset of the specifically related diabetes [24] . Furthermore, diabetes is a recognized risk factor for Sars-CoV2 infection [27] , and HMGB1 is known to be increased in diabetes [8] . CFTR and FOXO1 gene expression are reduced and high mobility group box 1 (HMGB1) is increased in the ovaries and serum of women with polycystic ovarian syndrome Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target	./cache/cord-354389-l2erwez8.txt	./txt/cord-354389-l2erwez8.txt