id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-355122-x3v80bdp	Desterke, Christophe	PPARγ cistrome repression during activation of lung monocyte-macrophages in severe COVID-19	2020-09-25		.txt	text/plain	7873	368	43	Overall, these results demonstrate for the first time, the involvement of the PPARγ complex in severe COVID-19 lung disease and suggest strongly its role in the major monocyte / macrophage-mediated inflammatory storm. A differentially expressed gene (DEG) analysis was performed on lung biopsies from COVID-19 patients and healthy donors; this revealed widespread repression of many gene pathways in COVID-19 lungs (Supplemental Figures 4A-4B) , which could affect major functionalities of the cells in this organ. Specifically, the gene-set enrichment analysis (performed using the 'hallmarks' gene set of the MsigDB database) highlighted repression of the mitosis spindle and p53 pathway (cell cycle gatekeeper) in samples of COVID-19 lungs compared to those of healthy donors (NES = -3.45 and -2.77, respectively, with p-value<0.001, Supplemental Figure 5A ). Mononuclear cells, monocytes, and macrophages were found in positions similar to the COVID-19 lung samples, suggesting major infiltrations in this tissue (Supplemental Figure 4E ) and confirming the results of the 'xcell' immune score analysis (Supplemental Figure 4C ).	./cache/cord-355122-x3v80bdp.txt	./txt/cord-355122-x3v80bdp.txt