id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-355131-ushv3n0z	Giuffrè, Mauro	COVID-19-Induced Thrombosis in Patients without Gastrointestinal Symptoms and Elevated Fecal Calprotectin: Hypothesis Regarding Mechanism of Intestinal Damage Associated with COVID-19	2020-09-16		.txt	text/plain	1451	84	45	Background: Patients with coronavirus infectious disease 2019 (COVID-19) and gastrointestinal symptoms showed increased values of fecal calprotectin (FC). At the time of writing this letter, the principal cause of mortality in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is respiratory failure with exudative diffuse alveolar damage and massive capillary congestion often accompanied by microthrombi or, in lower percentages, by generalized thrombotic microangiopathy, as reported by post-mortem examinations [1] . Additionally, an autoptic study on the small intestine of two COVID-19 patients showed endotheliitis of the submucosa vessels and evidence of direct viral infection of endothelial cells [6] . Regarding the clinical presentation, gastrointestinal symptoms are present in up to 28% of patients with COVID-19 [7] [8] [9] , and fecal SARS-CoV-2-RNA was detected in approximately 50% of positive individuals [8] [9] [10] . [5] proposed the role of fecal calprotectin (FC) as a marker of intestinal inflammation in COVID-19 patients who developed gastrointestinal (GI) symptoms.	./cache/cord-355131-ushv3n0z.txt	./txt/cord-355131-ushv3n0z.txt